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Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1.
- Source :
- Neuroscience Bulletin; 2020, Vol. 36 Issue 12, p1484-1499, 16p
- Publication Year :
- 2020
-
Abstract
- Trigeminal neuralgia is a debilitating condition, and the pain easily spreads to other parts of the face. Here, we established a mouse model of partial transection of the infraorbital nerve (pT-ION) and found that the Connexin 36 (Cx36) inhibitor mefloquine caused greater alleviation of pT-ION-induced cold allodynia compared to the reduction of mechanical allodynia. Mefloquine reversed the pT-ION-induced upregulation of Cx36, glutamate receptor ionotropic kainate 2 (GluK2), transient receptor potential ankyrin 1 (TRPA1), and phosphorylated extracellular signal regulated kinase (p-ERK) in the trigeminal ganglion. Cold allodynia but not mechanical allodynia induced by pT-ION or by virus-mediated overexpression of Cx36 in the trigeminal ganglion was reversed by the GluK2 antagonist NS102, and knocking down Cx36 expression in Nav1.8-expressing nociceptors by injecting virus into the orofacial skin area of Nav1.8-Cre mice attenuated cold allodynia but not mechanical allodynia. In conclusion, we show that Cx36 contributes greatly to the development of orofacial pain hypersensitivity through GluK2, TRPA1, and p-ERK signaling. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16737067
- Volume :
- 36
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Neuroscience Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 147410657
- Full Text :
- https://doi.org/10.1007/s12264-020-00594-4