プラセボ対照ランダム化二重盲検並行群間比較によるN-アセチルグルコサミンの 摂取が健常者の膝関節の違和感に及ぼす効果および安全性確認試験

The aim of present study was to evaluate the effect of N-acetylglucosamine administration on healthy subjects that exhibit knee pain or discomfort with 0 and 1 Kellgren-Lawrence grades. In this randomized, 12-week, double-blind, placebocontrolled study, we recruited 100 male and female participants, who were randomly assigned to test (containing 500 mg/day of N-acetylglucosamine) or placebo diet groups. The effect of diet on knee joint function was evaluated using the Japanese Orthopaedic Association (JOA), Japanese Knee Osteoarthritis Measure (JKOM), Knee Society (KS), and Japanese Knee Injury and Osteoarthritis Outcome Scores, as well as the Visual Analogue Scale (VAS) questionnaire. Furthermore, a safety assessment was performed based on physical parameters, hematology, blood biochemistry and urinalysis. Before the intervention, two subjects withdrew due to their own requests. No subjects were excluded from the analysis, as none met the exclusion criteria. The remaining 98 subjects were analyzed for efficacy. The results indicated that, after 12 weeks, JO A scores significantly improved in the test diet group compared with those in the placebo group. Although two adverse events were reported during the intervention, these were mild and judged by the investigator as unrelated to the diet. Therefore, our results suggest that oral administration of N-acetylglucosamine is effective to improve knee joint function without apparent adverse effects. [ABSTRACT FROM AUTHOR]