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Fabrication of polysaccharides-based hydrogel films for transdermal sustained delivery of Ibuprofen.
- Source :
- Cellulose; 2020, Vol. 27 Issue 17, p10277-10292, 16p
- Publication Year :
- 2020
-
Abstract
- Water-soluble polysaccharides of cellulose sulfate (NaCS) and chitosan hydrochloride (CHC) were chosen as the brick materials, while sodium tripolyphosphate (STPP) as a special "cement", the NaCS/CHC/STPP hydrogel films loaded with Ibuprofen were fabricated via self-assembly method. The prepared hydrogel films were characterized via SEM, FTIR, TGA and XRD. It manifested that the hydrogel films formed a dense three-dimensional network with a regular shape, and NaCS, CHC and STPP were involved in the formation of polyelectrolyte complex via electrostatic interaction. The Ibuprofen-loaded hydrogel films possessed respective loading and encapsulation efficiency of 43.15 ± 4.88% and 60.65 ± 4.68%. It verified that the hydrogel films had favourable sustained release profile during 1440 min test, in which Ibuprofen could penetrate through the skin of mouse in a transdermal drug delivery (TDD) model. The cytotoxicity assays indicated that the hydrogel films had non-toxicity and good biocompatibility. All these results shed light on the hydrogel films prepared could be used to design potential TDD vehicles. [ABSTRACT FROM AUTHOR]
- Subjects :
- TRANSDERMAL medication
IBUPROFEN
SODIUM tripolyphosphate
ELECTROSTATIC interaction
Subjects
Details
- Language :
- English
- ISSN :
- 09690239
- Volume :
- 27
- Issue :
- 17
- Database :
- Complementary Index
- Journal :
- Cellulose
- Publication Type :
- Academic Journal
- Accession number :
- 147199685
- Full Text :
- https://doi.org/10.1007/s10570-020-03503-0