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Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis.
- Source :
- Scientific Reports; 11/19/2020, Vol. 10 Issue 1, p1-9, 9p
- Publication Year :
- 2020
-
Abstract
- Early microcalcification is a feature of coronary plaques with an increased propensity to rupture and to cause acute coronary syndromes. In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radiotracer, <superscript>18</superscript>F-fluoride, was highly selective for hydroxyapatite deposition in atherosclerotic coronary plaque. Specifically, coronary <superscript>18</superscript>F-fluoride uptake had a high signal to noise ratio compared with surrounding myocardium that makes it feasible to identify coronary mineralisation activity. Areas of <superscript>18</superscript>F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprotein that mediates tissue mineralisation, and Runt-related transcription factor 2, a nuclear protein involved in osteoblastic differentiation. These results suggest that <superscript>18</superscript>F-fluoride is a non-invasive imaging biomarker of active coronary atherosclerotic mineralisation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 147103742
- Full Text :
- https://doi.org/10.1038/s41598-020-77391-6