Skeletal muscle AMPK activation: mounting evidence against a role in substrate utilization during acute exercise.

Keywords: AMPK; endurance training; exercise; skeletal muscle EN AMPK endurance training exercise skeletal muscle 5017 5019 3 11/16/20 20201115 NES 201115 Since the seminal findings that pharmacological activation of AMP-activated protein kinase (AMPK) increases skeletal muscle glucose uptake and fatty acid oxidation (FAO), AMPK has gained considerable interest as a regulator of fuel utilization during exercise. Inducible deletion of skeletal muscle AMPK a reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. [Extracted from the article]