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ERO1L promotes NSCLC development by modulating cell cycle‐related molecules.
- Source :
- Cell Biology International; Dec2020, Vol. 44 Issue 12, p2473-2484, 12p
- Publication Year :
- 2020
-
Abstract
- Lung cancer is the leading cause of cancer‐related death worldwide. Previous studies revealed that endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) played critical roles in the malignant behaviors of several cancer types, but its role in non‐small cell lung cancer (NSCLC) remained unclear. In this study, we identified 26 upregulated and 102 downregulated genes in NSCLC using bioinformatics analyses, and these genes were enriched in the biological processes of the cell cycle. ERO1L was remarkably upregulated in NSCLC and overexpression of ERO1L was associated with poor prognosis of NSCLC. ERO1L deficiency markedly suppressed NSCLC cell proliferation, colony formation, migration, and invasion. ERO1L depletion caused a dramatically decreased expression of cell cycle‐related factors in NSCLC cells. Collectively, our data validated that ERO1L could function as a tumor promoter in NSCLC, indicating the potential of targeting ERO1L for the treatment of NSCLC. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARCINOGENS
NON-small-cell lung carcinoma
LUNG cancer
Subjects
Details
- Language :
- English
- ISSN :
- 10656995
- Volume :
- 44
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Cell Biology International
- Publication Type :
- Academic Journal
- Accession number :
- 146948633
- Full Text :
- https://doi.org/10.1002/cbin.11454