Back to Search
Start Over
The amygdala in adolescents with attention-deficit/hyperactivity disorder: Structural and functional correlates of delay aversion.
- Source :
- World Journal of Biological Psychiatry; Nov2020, Vol. 21 Issue 9, p673-684, 12p
- Publication Year :
- 2020
-
Abstract
- Recent magnetic resonance imaging (MRI) studies implicate structural alterations of amygdala, a brain region responsible for processing and experiencing negative emotions, in adolescents with attention-deficit/hyperactivity disorder (ADHD). Here we examined ADHD-related structural correlates of amygdala functional activity elicited during a functional MRI task designed to test behavioural and brain responses to the imposition of delay – an event known to both elicit amygdala hyperactivation and aversity in ADHD. Structural MRI scans from 28 right-handed male adolescents with combined type ADHD and 32 age-matched controls were analysed. Regional grey matter volumes of ADHD and control participants (P[FWE] < 0.05) were correlated with delay aversion self-ratings and neural activity in response to delay-related cues on the Escape Delay Incentive fMRI task. ADHD was associated with significantly reduced volumes in bilateral amygdala, parahippocampal and temporal gyrus (P[FWE] < 0.05), greater basolateral amygdala activation to delay-related cues (P[FWE] < 0.05) and higher delay aversion self-ratings. Amygdala volume reductions were significantly correlated with, and statistically mediated the pathway from ADHD to, delay-cue-related amygdala hyperactivity (P < 0.01) and self-reported delay aversion (P < 0.01). We provide the first evidence of the functional significance of reduced amygdala volumes in adolescents with ADHD by highlighting its relation to delay-induced brain activity that is linked to delay aversion. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15622975
- Volume :
- 21
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- World Journal of Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 146806673
- Full Text :
- https://doi.org/10.1080/15622975.2019.1585946