Silencing of MDR 1 Gene in Cancer Cells by siRNA.

Authors :: Logashenko, E.B.
Vladimirova, A.V.
Repkova, M.N.
Venyaminova, A.G.
Chernolovskaya, E.L.
Vlassov, V.V.
Source :: Nucleosides, Nucleotides & Nucleic Acids; Jun2004, Vol. 23 Issue 6/7, p861-866, 6p, 2 Graphs
Publication Year :: 2004
Abstract: Inhibition of p-glycoprotein(PGP) expression and reverse of multidrug resistance(MDR) phenotype in KB-8-5 cells by synthetic 21-bp double-stranded oligoribonucleotides were investigated. siRNA constructs for the efficient down regulation of MDR1 that are active in nanomolar concentrations and cause reversal of MDR phenotype in cells were developed. [ABSTRACT FROM AUTHOR]