STUDY OF NEW AZO-AZOMETHINE DERIVATIVES OF SULFANILAMIDE : SYNTHESIS, CHARACTERIZATION, SPECTROSCOPIC, ANTIMICROBIAL, ANTIOXIDANT AND ANTICANCER ACTIVITY.

A complementary for previous study, series of azo-azomethine compounds (Sb6- Sb12) have been synthesized with magnificent yield by condensation reaction of 4-((3-formyl-4-hydroxy-5-methoxyphenyl)diazenyl) benzenesulfonamide and aniline derivatives. The new azo compound was prepared from sulfanilamide by converting it to diazonium salt followed by coupling reaction with 2-hydroxy-3-methoxybenzaldehyde in alkaline medium. The structures of synthesized azo and azoazomethine compounds have been established based on their spectral data (FT-IR,1HNMR,13CNMR)and elemental analysis (C, H, N). The purity of compound and evaluation of Rf value were determined by TLC. The antimicrobial activity of azo-azomethine compounds have been tested in vitro against bacteria (Staphylococcus aureus, Escherichia coli and Klepsilia pneumonia) and fungi (Candida glabrata, Candida albicane and Aspergillus niger) by agar diffusion method, to assess their inhibiting potential. Also, the antioxidant and anticancer efficiency of azo-azomethine compounds have been calculated. [ABSTRACT FROM AUTHOR]