Back to Search
Start Over
A Novel NiFe 2 O 4 /Paper-Based Magnetoelastic Biosensor to Detect Human Serum Albumin.
- Source :
- Sensors (14248220); Sep2020, Vol. 20 Issue 18, p5286, 1p
- Publication Year :
- 2020
-
Abstract
- For the first time, a novel NiFe<subscript>2</subscript>O<subscript>4</subscript>/paper-based magnetoelastic (ME) biosensor was developed for rapid, sensitive, and portable detection of human serum albumin (HSA). Due to the uniquely magnetoelastic effect of NiFe<subscript>2</subscript>O<subscript>4</subscript> nanoparticles and the excellent mechanical properties of the paper, the paper-based ME biosensor transforms the surface stress signal induced by the specific binding of HSA and antibody modified on the paper into the electromagnetic signal. The accumulated binding complex generates a compressive stress on the biosensor surface, resulting in a decrease in the biosensor's static magnetic permeability, which correlates to the HSA concentrations. To improve the sensitivity of the biosensor, the concentration of NiFe<subscript>2</subscript>O<subscript>4</subscript> nanofluid and the impregnated numbers of the NiFe<subscript>2</subscript>O<subscript>4</subscript> nanofluid-impregnated papers were optimized. The experimental results demonstrated that the biosensor exhibited a linear response to HSA concentrations ranging from 10 μg∙mL<superscript>−1</superscript> to 200 μg∙mL<superscript>−1</superscript>, with a detection limit of 0.43 μg∙mL<superscript>−1</superscript>, which is significantly lower than the minimal diagnosis limit of microalbuminuria. The NiFe<subscript>2</subscript>O<subscript>4</subscript>/paper-based ME biosensor is easy to fabricate, and allows the rapid, highly-sensitive, and selective detection of HSA, providing a valuable analytical device for early monitoring and clinical diagnosis of microalbuminuria and nephropathy. This study shows the successful integration of the paper-based biosensor and the ME sensing analytical method will be a highly-sensitive, easy-to-use, disposable, and portable alternative for point-of-care monitoring. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14248220
- Volume :
- 20
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Sensors (14248220)
- Publication Type :
- Academic Journal
- Accession number :
- 146713744
- Full Text :
- https://doi.org/10.3390/s20185286