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Effects of Probiotics Administration on Human Metabolic Phenotype.

Authors :
Ghini, Veronica
Tenori, Leonardo
Pane, Marco
Amoruso, Angela
Marroncini, Giada
Squarzanti, Diletta Francesca
Azzimonti, Barbara
Rolla, Roberta
Savoia, Paola
Tarocchi, Mirko
Galli, Andrea
Luchinat, Claudio
Source :
Metabolites (2218-1989); Oct2020, Vol. 10 Issue 10, p396-396, 1p
Publication Year :
2020

Abstract

The establishment of the beneficial interactions between the host and its microbiota is essential for the correct functioning of the organism, since microflora alterations can lead to many diseases. Probiotics improve balanced microbial communities, exerting substantial health-promoting effects. Here we monitored the molecular outcomes, obtained by gut microflora modulation through probiotic treatment, on human urine and serum metabolic profiles, with a metabolomic approach. Twenty-two subjects were enrolled in the study and administered with two different probiotic types, both singularly and in combination, for 8 weeks. Urine and serum samples were collected before and during the supplementation and were analyzed by nuclear magnetic resonance (NMR) spectroscopy and statistical analyses. After eight weeks of treatment, probiotics deeply influence the urinary metabolic profiles of the volunteers, without significantly altering their single phenotypes. Anyway, bacteria supplementation tends to reduce the differences in metabolic phenotypes among individuals. Overall, the effects are recipient-dependent, and in some individuals, robust effects are already well visible after four weeks. Modifications in metabolite levels, attributable to each type of probiotic administration, were also monitored. Metabolomic analysis of biofluids turns out to be a powerful technique to monitor the dynamic interactions between the microflora and the host, and the individual response to probiotic assumption. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22181989
Volume :
10
Issue :
10
Database :
Complementary Index
Journal :
Metabolites (2218-1989)
Publication Type :
Academic Journal
Accession number :
146660914
Full Text :
https://doi.org/10.3390/metabo10100396