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Molecular targets for neuroprotection.
- Source :
- Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders; Sep2004 Supplement 1, Vol. 5, p14-18, 5p
- Publication Year :
- 2004
-
Abstract
- Amyotrophic lateral sclerosis (ALS) is a fatal paralytic neurodegenerative disorder. Experimental models of ALS such as the transgenic rodents expressing mutant superoxide dimutase-1 are playing a pivotal role in our understanding of ALS pathogenesis, and in our testing of new therapeutic interventions aimed at protecting against neurodegeneration. Apoptosis has emerged as a significant pathogenic factor in several neurodegenerative diseases, including ALS. Constructed of multiple interacting molecules, the apoptosis machinery offers a host of attractive targets for pharmacological and genetic interventions to be tested in experimental models of ALS. Information generated by these pre-clinical studies holds the promise to provide sound scientific basis for the development of effective neuroprotective therapies for ALS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14660822
- Volume :
- 5
- Database :
- Complementary Index
- Journal :
- Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 14664849
- Full Text :
- https://doi.org/10.1080/1734470410019780