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Acute Cardiovascular Events Associated With Influenza in Hospitalized Adults : A Cross-sectional Study.
- Source :
- Annals of Internal Medicine; 10/20/2020, Vol. 173 Issue 8, p605-613, 9p, 7 Charts
- Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Influenza may contribute to the burden of acute cardiovascular events during annual influenza epidemics.<bold>Objective: </bold>To examine acute cardiovascular events and determine risk factors for acute heart failure (aHF) and acute ischemic heart disease (aIHD) in adults with a hospitalization associated with laboratory-confirmed influenza.<bold>Design: </bold>Cross-sectional study.<bold>Setting: </bold>U.S. Influenza Hospitalization Surveillance Network during the 2010-to-2011 through 2017-to-2018 influenza seasons.<bold>Participants: </bold>Adults hospitalized with laboratory-confirmed influenza and identified through influenza testing ordered by a practitioner.<bold>Measurements: </bold>Acute cardiovascular events were ascertained using discharge codes from the International Classification of Diseases (ICD), Ninth Revision, Clinical Modification, and ICD, 10th Revision. Age, sex, race/ethnicity, tobacco use, chronic conditions, influenza vaccination, influenza antiviral medication, and influenza type or subtype were included as exposures in logistic regression models, and marginal adjusted risk ratios and 95% CIs were estimated to describe factors associated with aHF or aIHD.<bold>Results: </bold>Among 89 999 adults with laboratory-confirmed influenza, 80 261 had complete medical record abstractions and available ICD codes (median age, 69 years [interquartile range, 54 to 81 years]) and 11.7% had an acute cardiovascular event. The most common such events (non-mutually exclusive) were aHF (6.2%) and aIHD (5.7%). Older age, tobacco use, underlying cardiovascular disease, diabetes, and renal disease were significantly associated with higher risk for aHF and aIHD in adults hospitalized with laboratory-confirmed influenza.<bold>Limitation: </bold>Underdetection of cases was likely because influenza testing was based on practitioner orders. Acute cardiovascular events were identified by ICD discharge codes and may be subject to misclassification bias.<bold>Conclusion: </bold>In this population-based study of adults hospitalized with influenza, almost 12% of patients had an acute cardiovascular event. Clinicians should ensure high rates of influenza vaccination, especially in those with underlying chronic conditions, to protect against acute cardiovascular events associated with influenza.<bold>Primary Funding Source: </bold>Centers for Disease Control and Prevention. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLUENZA complications
INFLUENZA prevention
INFLUENZA vaccines
LENGTH of stay in hospitals
RESEARCH
MYOCARDIAL ischemia
CROSS-sectional method
RESEARCH methodology
ANTIVIRAL agents
EVALUATION research
MEDICAL cooperation
COMPARATIVE studies
HOSPITAL care
INFLUENZA
RESEARCH funding
HEART failure
ACUTE diseases
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00034819
- Volume :
- 173
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Annals of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 146561431
- Full Text :
- https://doi.org/10.7326/M20-1509