Estimation Ferritin Levels and the Correlation with Serum Iron Levels, Enzyme Liver and Excretory Function of Liver in Β-Thalassemia Major.

The study was designed to evaluate the medical relevance of ferritin levels with Iron levels, liver enzymes and Bilirubin levels and alkaline phosphatase (ALP) levels in beta-thalassemia patients. Blood samples were taken from thalassemia departments of a ministry of healthy hospitals. Forty three children with thalassemia (study group) and Forty three healthy controls (group control). We found that significantly increased ferritin level, measured as an index of iron overload, was demonstrated in thalassemia (p< 0.01). The mean serum iron level in children with thalassemia was significantly higher than the control group (p< 0.02). In addition, the mean serum liver enzymes levels [glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT)], bilirubin levels, ALP levels in thalassemia patients was significantly higher than the control group. Moreover, a positive connexion was also observed between ferritin levels and iron levels and also, we found a positive connexion between liver enzyme level, bilirubin levels and ALP levels with ferritin levels in the beta thalassemia patients [ABSTRACT FROM AUTHOR]