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Late Pregnancy Vitamin D Deficiency is Associated with Doubled Odds of Birth Asphyxia and Emergency Caesarean Section: A Prospective Cohort Study.
- Source :
- Maternal & Child Health Journal; Nov2020, Vol. 24 Issue 11, p1412-1418, 7p, 4 Charts
- Publication Year :
- 2020
-
Abstract
- Objectives: The aim of this prospective cohort study was to investigate the associations between maternal vitamin D status in late pregnancy and emergency caesarean section (EMCS) and birth asphyxia, in a population based sample of women in Sweden. Methods: Pregnant women were recruited at the antenatal care in Sweden and 1832 women were included after exclusion of miscarriages, terminated pregnancies and missing data on vitamin D status. Mode of delivery was retrieved from medical records. EMCS was defined as caesarean section after onset of labour. Birth asphyxia was defined as either 5 min Apgar score < 7 or arterial umbilical cord pH < 7.1. Serum was sampled in the third trimester of pregnancy (T3) and 25-hydroxyvitamin D (25OHD) was analysed by liquid chromatography tandem mass spectrometry. Vitamin D deficiency was defined as 25OHD < 30 nmol/L, and associations were studied using logistic regression analysis and expressed as adjusted odds ratios (AOR). Results: In total, 141 (7.7%) women had an EMCS and 58 (3.2%) children were born with birth asphyxia. Vitamin D deficiency was only associated with higher odds of EMCS in women without epidural anaesthesia (AOR = 2.01, p = 0.044). Vitamin D deficiency was also associated with higher odds of birth asphyxia (AOR = 2.22, p = 0.044). Conclusions for Practice: In this Swedish prospective population-based cohort study, vitamin D deficiency in late pregnancy was associated with doubled odds of birth asphyxia and with EMCS in deliveries not aided by epidural anaesthesia. Prevention of vitamin D deficiency among pregnant women may reduce the incidence of EMCS and birth asphyxia. The mechanism behind the findings require further investigation. [ABSTRACT FROM AUTHOR]
- Subjects :
- APGAR score
ASPHYXIA neonatorum
CESAREAN section
EMERGENCY medical services
LIQUID chromatography
LONGITUDINAL method
MASS spectrometry
MEDICAL records
PREGNANT women
RESEARCH funding
RISK assessment
VITAMIN D
VITAMIN D deficiency
WOMEN'S health
LOGISTIC regression analysis
DESCRIPTIVE statistics
ACQUISITION of data methodology
DISEASE complications
DISEASE risk factors
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 10927875
- Volume :
- 24
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Maternal & Child Health Journal
- Publication Type :
- Academic Journal
- Accession number :
- 146432811
- Full Text :
- https://doi.org/10.1007/s10995-020-02999-z