Design, Synthesis, Anti-Cancer Activity, and in silico Studies of Novel Imidazo[1,2-a]pyridine Derivatives.

A novel series of imidazo [1,2-a]pyridine derivatives has been designed, synthesized and tested for the anti-proliferative activity against three different human cancer cell lines. Most of the synthesized compounds exhibit anti-proliferative activity with IC₅₀ values ranging from 5.35–59.8 μM. Six compounds demonstrate efficient inhibition of growth of all cell lines with IC₅₀ values close to that of standard drug, and the compound 16h is more potent than the standard drug cisplatin for the HeLa cell line. [ABSTRACT FROM AUTHOR]