Chiral Trifluoromethylated Pyrrolidines via Cu–Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition.

An efficient access to chiral pyrrolidine derivatives bearing one trifluoromethylated quaternary stereogenic centers is developed through Cu(I)/(S)‐TF‐BiphamPhos‐catalyzed asymmetric 1,3‐dipolar cycloaddition of azomethine ylides with tert‐butyl 2‐(trifluoromethyl)acrylate in moderate to high yields, excellent diastereoselectivities and good enantioselectivities (up to 95% yield, >20 : 1 dr, 89% ee). [ABSTRACT FROM AUTHOR]