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Poly‐L‐lactide scaffolds with super pores obtained by freeze‐extraction method.

Authors :
Budnicka, Monika
Kołbuk, Dorota
Ruśkowski, Paweł
Gadomska‐Gajadhur, Agnieszka
Source :
Journal of Biomedical Materials Research, Part B: Applied Biomaterials; Nov2020, Vol. 108 Issue 8, p3162-3173, 12p
Publication Year :
2020

Abstract

A nonplanar polylactide scaffold to be used in tissue engineering was obtained by freeze‐extraction method. Properties of the scaffold were modified by adding Eudragit® E100. The impact of the modification on morphology, porosity and pore size, mass absorbability, mechanical properties was determined. Scanning electron microscopy (SEM), hydrostatic weighing test, static compression test was used to this end. The chemical composition of the scaffold was defined based on infrared spectroscopy (FTIR) and energy‐dispersive X‐ray spectroscopy (EDX). Biocompatibility was confirmed by quantitative tests and microscopic observation. The obtained results show that the obtained scaffolds may be applied as a carrier of hydrophilic cellular growth factors for more efficient tissue regeneration. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15524973
Volume :
108
Issue :
8
Database :
Complementary Index
Journal :
Journal of Biomedical Materials Research, Part B: Applied Biomaterials
Publication Type :
Academic Journal
Accession number :
146250949
Full Text :
https://doi.org/10.1002/jbm.b.34642