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Occurrence of metachronous second primary cancer in head and neck cancer survivors: A systematic review and meta‐analysis of the literature.
- Source :
- European Journal of Cancer Care; Sep2020, Vol. 29 Issue 5, p1-17, 17p
- Publication Year :
- 2020
-
Abstract
- Objective: Head and neck cancer (HNC) is the sixth leading cancer worldwide with approximately 600,000 new cases per year. Several studies suggest that HNC survivors may have an increased risk of developing second primary cancers (SPCs). A systematic review and meta‐analysis was performed aiming to quantify the overall and site‐specific risk of metachronous SPCs in HNC survivors. Methods: PubMed, Web of Science and Scopus were searched to identify studies published until October 2019. Studies investigating the standardised incidence ratio (SIR) of metachronous SPC were included. A random‐effects meta‐analysis was performed to calculate the overall and site‐specific SIRs. Newcastle–Ottawa Scale was used to assess the study's quality. Heterogeneity was quantified using the I2 statistics and explored using meta‐regression. Results: Twenty‐six studies were included in the systematic review. Studies differed by the definition of metachronous SPC used. For the meta‐analyses, the studies were grouped according to these definitions. In the three groups, the overall risk of metachronous SPC was increased. The highest SPC risk was for oropharynx, oesophagus and lung. Conclusions: Head and neck cancer survivors are at increased overall risk of metachronous SPCs. The canonical upper aerodigestive sites, HNLE (head and neck, oesophagus and lung), were the SPC sites with the highest risk. Implication for Cancer Survivors: Our results emphasise the importance of targeted surveillance strategies aimed at early detection and tertiary preventive interventions. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER patients
CHI-squared test
CONFIDENCE intervals
ESOPHAGEAL tumors
HEAD tumors
LUNG tumors
MEDLINE
META-analysis
NECK tumors
ONLINE information services
RISK assessment
SYSTEMATIC reviews
DISEASE incidence
DATA analysis software
DESCRIPTIVE statistics
SECONDARY primary cancer
INFERENTIAL statistics
OROPHARYNGEAL cancer
DISEASE complications
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 09615423
- Volume :
- 29
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- European Journal of Cancer Care
- Publication Type :
- Academic Journal
- Accession number :
- 146138710
- Full Text :
- https://doi.org/10.1111/ecc.13255