Antibacterial and antioxidant activity of wild-growing Angelica species (Apiaceae) from Balkan Peninsula against human pathogenic bacteria: 'in honor of famous natural historian Dr Josif Pančić (1814-1888)'.

This is the first study on antioxidant and antibacterial activity of essential oils of A. sylvestris and A. pancicii against the human pathogens. In the oil of A. sylvestris, the main compounds were limonene (75.3%) and α-pinene (9.6%), while in the oil of A. pancicii the main compounds were β-phellandrene (54.9%), α-pinene (14.5%) and α-phellandrene (4.05%). The results of ABTS have shown that antioxidant activity ranged between 1.48 and 2.07 mg VitC/g for 30 μL/mL of tested concentration. IC₅₀ values in DPPH assay ranged between 59.895 and 149.498 mg/mL of tested concentrations. Antibacterial activity of the essential oils and antibiotics against pathogenic bacterial strains was investigated using microwell dilution method. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were in the ranges of MIC/MBC = 0.11/54.40 mg/mL and 0.10/48.20 mg/mL (respectively). When combined with antibiotics, the oils have exhibited synergism and may reduce the minimum effective dose of antibiotics required and minimize its side effects. [ABSTRACT FROM AUTHOR]