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LepR-Expressing Stem Cells Are Essential for Alveolar Bone Regeneration.
- Source :
- Journal of Dental Research; Oct2020, Vol. 99 Issue 11, p1279-1286, 8p, 2 Diagrams, 3 Graphs
- Publication Year :
- 2020
-
Abstract
- Stem cells play a critical role in bone regeneration. Multiple populations of skeletal stem cells have been identified in long bone, while their identity and functions in alveolar bone remain unclear. Here, we identified a quiescent leptin receptor-expressing (LepR+) cell population that contributed to intramembranous bone formation. Interestingly, these LepR+ cells became activated in response to tooth extraction and generated the majority of the newly formed bone in extraction sockets. In addition, genetic ablation of LepR+ cells attenuated extraction socket healing. The parabiosis experiments revealed that the LepR+ cells in the healing sockets were derived from resident tissue rather than peripheral blood circulation. Further studies on the mechanism suggested that these LepR+ cells were responsive to parathyroid hormone/parathyroid hormone 1 receptor (PTH/PTH1R) signaling. Collectively, we demonstrate that LepR+ cells, a postnatal skeletal stem cell population, are essential for alveolar bone regeneration of extraction sockets. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00220345
- Volume :
- 99
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Dental Research
- Publication Type :
- Academic Journal
- Accession number :
- 146011607
- Full Text :
- https://doi.org/10.1177/0022034520932834