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Changes in Sexual Behaviors in Men Who Have Sex with Men: A Comparison Between the Double-Blind and Open-Label Extension Phases of the ANRS-IPERGAY Trial.
- Source :
- AIDS & Behavior; Nov2020, Vol. 24 Issue 11, p3093-3106, 14p, 4 Charts, 6 Graphs
- Publication Year :
- 2020
-
Abstract
- Pre-Exposure Prophylaxis (PrEP) is changing the landscape of HIV prevention, and may bring changes in sexual behaviors. The double-blind phase (DBP) and open-label extension (OLE) study of the ANRS-IPERGAY trial allowed us to assess changes in sexual behavior of men who have sex with men (MSM) taking sexual activity-based (i.e., on-demand) PrEP. Generalized Estimating Equation (GEE) models found a significant decrease in the number of sexual partners (Coefficient [CI95%], p value; − 0.37[− 0.70 to − 0.04], p = 0.03) between the DBP and OLE as well as in the number of sexual relations (− 0.25 [− 0.49 to 0.00], 0.04). GEE estimates also showed that respondents' most recent sexual relation was less likely to have been with an unknown casual partner during the OLE than during the DBP (Odds Ratio [CI95%], p value: 0.75[0.62–0.92], 0.005). Furthermore, they showed an increase in the proportion of condomless anal sex in the OLE (1.32[1.04–1.67], 0.02), a decrease in the proportion of 'suboptimal PrEP adherence' over time (0.75[0.58–0.97], p = 0.03), a decrease in PrEP only use (0.73[0.55–0.96], 0.03) and in both PrEP and condom use over time (0.70[0.51–0.95], 0.02) and finally, a decrease in alcohol consumption between the DBP and OLE (0.74[0.61–0.90], 0.002). We observed both protective and risky behaviors in terms of HIV and STI risk after on-demand PrEP uptake in the OLE phase. Our findings are consistent with results from previous PrEP trials. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10907165
- Volume :
- 24
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- AIDS & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 145976140
- Full Text :
- https://doi.org/10.1007/s10461-020-02864-8