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Antibactericidal nanoclay-based biomaterial for sustained delivery of tetracycline hydrochloride.
- Source :
- Bulletin of Materials Science; 2020, Vol. 43 Issue 1, p1-11, 11p
- Publication Year :
- 2020
-
Abstract
- Nanoclay-based drug delivery vehicle has acquired immense recognition owing to its unique physico-chemical properties. In this study, tetracycline hydrochloride (TCH) drug was intercalated into the interlayer gallery of montmorillonite (Mt) clay by a cation exchange process. The intercalated nanocomposites were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive X-ray and thermogravimetric study. It was evident from the characterization that TCH drug was successfully intercalated into the interlayer gallery of Mt clay. These clay-based formulations exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria on analyses via zone inhibition methods. An in-vitro drug release study was performed in phosphate buffer at physiological temperature and interestingly it exhibited sustained and controlled release of TCH from the nanocomposites, after an initial burst-out effect. Overall, this study showed that these nanocomposite materials have immense potential for use in controlled drug delivery strategies for antibacterial treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02504707
- Volume :
- 43
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Bulletin of Materials Science
- Publication Type :
- Academic Journal
- Accession number :
- 145376960
- Full Text :
- https://doi.org/10.1007/s12034-020-02221-4