A tree shrew model for steroid-associated osteonecrosis.

The article highlights a study we used a low dose of lipopolysaccharide (LPS) combined with a high dose of methylprednisolone (MPS) to induce a model of femoral head necrosis in tree shrews. It discusses that the model was established in 12 weeks as determined by biochemical analysis, micro-CT examinations, histological analyses, and scanning electron microscopy; and concludes that it replicated a tree shrew model of human hormone-induced osteonecrosis.