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Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy.
- Source :
- Expert Review of Medical Devices; Jul2020, Vol. 17 Issue 7, p707-720, 14p
- Publication Year :
- 2020
-
Abstract
- Type 1 diabetes is a lifelong disease with high management burden. The majority of people with type 1 diabetes fail to achieve glycemic targets. Algorithm-driven automated insulin delivery (closed-loop) systems aim to address these challenges. This review provides an overview of commercial and emerging closed-loop systems. We review safety and efficacy of commercial and emerging hybrid closed-loop systems. A literature search was conducted and clinical trials using day-and-night closed-loop systems during free-living conditions were used to report on safety data. We comment on efficacy where robust randomized controlled trial data for a particular system are available. We highlight similarities and differences between commercial systems. Study data shows that hybrid closed-loop systems are safe and effective, consistently improving glycemic control when compared to standard therapy. While a fully closed-loop system with minimal burden remains the end-goal, these hybrid closed-loop systems have transformative potential in diabetes care. [ABSTRACT FROM AUTHOR]
- Subjects :
- INSULIN pumps
DIABETES
TYPE 1 diabetes
CLOSED loop systems
GLYCEMIC control
Subjects
Details
- Language :
- English
- ISSN :
- 17434440
- Volume :
- 17
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Expert Review of Medical Devices
- Publication Type :
- Academic Journal
- Accession number :
- 145199400
- Full Text :
- https://doi.org/10.1080/17434440.2020.1784724