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Impact of Cognitive Frailty on Activities of Daily Living, Cognitive Function, and Conversion to Dementia Among Memory Clinic Patients with Mild Cognitive Impairment.
- Source :
- Journal of Alzheimer's Disease; 2020, Vol. 76 Issue 3, p895-903, 9p
- Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Very few studies have investigated the impact of cognitive frailty in clinical settings, especially in memory clinic populations.<bold>Objective: </bold>To examine the impact of cognitive frailty on activities of daily living (ADL), cognitive function, and conversion to dementia among memory clinic patients with mild cognitive impairment (MCI).<bold>Methods: </bold>The subjects of this retrospective study were 248 MCI patients (mean age, 76.3±5.4 years; females, 60.9%). All subjects completed a comprehensive geriatric assessment at baseline and at least one assessment during 3-year follow-up. Frailty was defined by generating a frailty index (FI), and MCI patients with frailty (FI≥0.25) were considered to represent cognitive frailty. As primary outcomes, the Barthel Index, Mini-Mental State Examination, and incident dementia were evaluated during follow-up. At baseline, patients were assessed for apolipoprotein E (APOE) phenotype. A linear mixed model, as well as a Cox proportional hazards regression model with adjustment for confounding variables, was performed.<bold>Results: </bold>Of these patients, 75 (30.2%) were classified as cognitive frail. APOEɛ4 carriers accounted for 26.7% of those with cognitive frailty and 44.5% of those without (p = 0.008). Cognitive frail patients showed a faster ADL decline (estimate, -1.04; standard error, 0.38; p = 0.007) than patients without cognitive frailty. Cognitive frailty was not associated with cognitive decline and incident dementia.<bold>Conclusion: </bold>Our findings demonstrated cognitive frailty increases the risk of dependence but not cognitive outcomes. Cognitive frailty may have heterogeneous conditions, including APOEɛ4-related pathologies, which may affect the cognitive trajectories of patients with MCI. [ABSTRACT FROM AUTHOR]
- Subjects :
- MINI-Mental State Examination
ACTIVITIES of daily living
MILD cognitive impairment
PROPORTIONAL hazards models
COGNITIVE ability
APOLIPOPROTEIN E
DEMENTIA
MEMORY
RESEARCH
FRAIL elderly
RESEARCH methodology
COGNITION
GERIATRIC assessment
MEDICAL cooperation
EVALUATION research
COMPARATIVE studies
QUESTIONNAIRES
BARTHEL Index
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 76
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 145171306
- Full Text :
- https://doi.org/10.3233/JAD-191135