Water-soluble amphiphilic ruthenium(II) polypyridyl complexes as potential light-activated therapeutic agents.

Authors :: Estalayo-Adrián, Sandra
Blasco, Salvador
Bright, Sandra A.
McManus, Gavin J.
Orellana, Guillermo
Williams, D. Clive
Kelly, John M.
Gunnlaugsson, Thorfinnur
Source :: Chemical Communications; 8/21/2020, Vol. 56 Issue 65, p9332-9335, 4p
Publication Year :: 2020
Abstract: Two water-soluble amphiphilic Ru(II) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells. [ABSTRACT FROM AUTHOR]

Subjects :: RUTHENIUM
CERVICAL cancer
CANCER cells
RUTHENIUM compounds
LIGANDS (Chemistry)

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