Pharmacokinetics of cephalexin in sea bream,Sparus aurata(L.), after a single intraperitoneal injection.

The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg^-1). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non-compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two-compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml^-1 kg^-1 1 h post-treatment. The area under the curve (AUC) cephalexin was 17.394 mg·h kg^-1 and the elimination half-life of 1.83 h. [ABSTRACT FROM AUTHOR]