Current vector research challenges in the greater Mekong subregion for dengue, Malaria, and Other Vector-Borne Diseases: A report from a multisectoral workshop March 2019.

Controlled human infection models, particularly if using vector delivery of pathogens as is done with malaria [[48]], may support new insights into pathogen dose-dependence of human-to-vector transmission and will help define parameters for effective interventions by vaccines, antimalarials, or vector saliva-based therapeutics for the goals of transmission reduction [[49]]. Exposure risk and transmission Exposure to the vector is the first and necessary process leading to transmission to the human or infection of the vector. Prevention of reintroduction of vector-borne pathogens is essential, particularly in the populous GMS, and must address the characterization of potential secondary vectors, possible introduction of exotic vectors, or importation of pathogens by visitors and migrants [[115]]. Given the immunogenicity of vector saliva in the context of pathogen transmission and infection, there was also agreement that development of controlled human infection models could provide important immunological and mechanistic insights into the success of transmission of VBD. [Extracted from the article]