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Rhodium‐Catalyzed Cascade Reactions of Indoles with 4‐Hydroxy‐2‐Alkynoates for the Synthesis of Indole‐Fused Polyheterocycles.
- Source :
- Advanced Synthesis & Catalysis; 7/29/2020, Vol. 362 Issue 14, p2953-2960, 8p
- Publication Year :
- 2020
-
Abstract
- Herein, an efficient and regioselective Rh(III)‐catalyzed [4+2] annulation/lactonization cascade of indoles with 4‐hydroxy‐2‐alkynoates at room temperature to access the furo[3′,4′:4,5]pyrimido[1,6‐a]indole‐1,5(3H,4H)‐diones is described. This method features mild reaction conditions, operational simplicity, excellent regioselectivity, broad substrate scope with good functional group tolerance, and good to excellent yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- INDOLE
FUNCTIONAL groups
ANNULATION
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 362
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 144829500
- Full Text :
- https://doi.org/10.1002/adsc.202000493