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Clinical, microscopic and molecular presentation in pediatric versus adult old world cutaneous Leishmaniasis.
- Source :
- Pediatric Dermatology; Jul2020, Vol. 37 Issue 4, p656-660, 5p, 1 Color Photograph, 1 Illustration, 2 Charts
- Publication Year :
- 2020
-
Abstract
- Background: Cutaneous leishmaniasis (CL) is an emerging uncontrolled tropical parasitic disease in endemic and nonendemic areas with a high prevalence in the pediatric age group. Method: A total of 382 individuals from Lebanon, Saudi Arabia, Pakistan, and Syria diagnosed with CL by punch biopsy/scrapings were grouped into adults (>18 years) and pediatrics (≤18 years). Data recorded included clinical features [number, location, type, size, and extensiveness (size larger than 3 cm, more than 5 lesions per patient, lesion present for more than 12 months, special types, disfiguring lesion or closeness to vital sensory organs) of lesions] and microscopic findings [Ridley's Parasitic Index and Ridley's Pattern]. In addition, molecular confirmation and speciation were performed. Results: In comparison with adults, patients in the pediatric group (n = 158, 41.4%) showed significantly higher number of lesions, more facial involvement, and more extensive disease (P <.05). Microscopically, a more advanced Ridley's pattern was observed. The other variables did not show statistical difference between the two groups. Conclusion: Historically, CL has been known to be a neglected tropical disease of poverty and pediatric predilection. In our pediatric group, CL manifests with more extensive disease clinically mirrored by more advanced lesions microscopically. [ABSTRACT FROM AUTHOR]
- Subjects :
- CUTANEOUS leishmaniasis
PARASITIC diseases
ENDEMIC diseases
TROPICAL medicine
Subjects
Details
- Language :
- English
- ISSN :
- 07368046
- Volume :
- 37
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Pediatric Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 144749242
- Full Text :
- https://doi.org/10.1111/pde.14195