Back to Search
Start Over
A mitochondria-targeting ratiometric fluorescent probe for the detection of sulfur dioxide in living cells.
- Source :
- New Journal of Chemistry; 7/28/2020, Vol. 44 Issue 28, p11988-11992, 5p
- Publication Year :
- 2020
-
Abstract
- Sulfur dioxide (SO<subscript>2</subscript>) plays critical biological roles in living systems, and participates in a series of physiological and pathological processes. Aspartate aminotransferase 2 (AAT-2) catalyzes L -cysteine to produce endogenous SO<subscript>2</subscript>, which is mainly expressed in the mitochondria of cells. Herein, we present a new mitochondria-targeting and ratiometric fluorescent probe (MNP) for the detection of SO<subscript>2</subscript> in living cells. The probe MNP employed a positively charged benzopyrylium moiety as the response site for SO<subscript>2</subscript>, and displayed a selective ratiometric response to SO<subscript>2</subscript> on the basis of a FRET mechanism. Biological experiments demonstrated that the probe MNP was mainly distributed in mitochondria and could be used for the imaging of SO<subscript>2</subscript> in living cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 44
- Issue :
- 28
- Database :
- Complementary Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 144670056
- Full Text :
- https://doi.org/10.1039/d0nj02461a