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Serum copeptin and copeptin/NT-proBNP ratio -- new tools to differentiate takotsubo syndrome from acute myocardial infarction.
- Source :
- Folia Medica Cracoviensia; 2020, Vol. 60 Issue 1, p5-13, 9p
- Publication Year :
- 2020
-
Abstract
- Background: Today no established biomarkers are available for the early diagnosis of takotsubo syndrome and its differentiation from ST-segment elevation myocardial infarction. We hypothesized that copeptin and copeptin/NT-proBNP ratio may serve a routine marker combination for non-invasive differentiation. Methods: The study compared the serum concentrations of copeptin, troponin I (TnI) and NT-proBNP in 19 consecutive women diagnosed with takotsubo syndrome according to the Mayo Clinic criteria and 10 consecutive women diagnosed with ST-segment elevation myocardial infarction. Results: Copeptin concentrations were significantly lower in patients with takotsubo syndrome than in patients with ST-segment elevation myocardial infarction. The diagnostic accuracy to distinguish takotsubo syndrome from ST-segment elevation myocardial infarction is highest for copeptin/NTproBNP ratio, copeptin/TnI at admission ratio and copeptin alone (AUC 0.8713, 0.8538, 0.8480, respectively). Conclusions: The serum copeptin to NTproBNP ratio could be an additional tool in the non-invasive differentiation between takotsubo syndrome and ST-segment elevation myocardial infarction. However, further researches are needed. [ABSTRACT FROM AUTHOR]
- Subjects :
- TAKOTSUBO cardiomyopathy
COPEPTINS
TROPONIN
MYOCARDIAL infarction
PATIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 00155616
- Volume :
- 60
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Folia Medica Cracoviensia
- Publication Type :
- Academic Journal
- Accession number :
- 144611379
- Full Text :
- https://doi.org/10.24425/fmc.2020.133481