Cadherin‐related family member 3 upregulates the effector functions of eosinophils.

Keywords: asthma; eosinophils; virus EN asthma eosinophils virus 1805 1809 5 07/14/20 20200701 NES 200701 Acute respiratory infections including rhinovirus (RV) infections are a major cause of asthma exacerbations. Along with increased CDHR3 expression on the cell surface, transfection with CDHR3-Y SB 529 sb also increased eosinophil adhesion compared to CDHR3-C SB 529 sb or the negative control (Figure 2A). These findings suggest that the difference in eosinophil adhesion was due to the level of surface expression of CDHR3 protein, but not due to the different ability of the CDHR3 variants to induce eosinophil adhesion. Given the close association between eosinophilic inflammation and asthma exacerbation, CDHR3-Y SB 529 sb could promote eosinophil adhesion and proinflammatory functions linked to asthma exacerbations. [Extracted from the article]