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Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA.
- Source :
- Pharmaceutics; Jun2020, Vol. 12 Issue 6, p545, 1p
- Publication Year :
- 2020
-
Abstract
- MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions. In this study, we attempted to develop a novel drug delivery system using anti-exosome antibody–anti-miR oligonucleotide complexes (ExomiR-Tracker) to hijack exosomes to carry anti-miR oligonucleotides inside exosome-recipient cells. We found that ExomiR-Tracker bound to the exosomes, and then the complexes were introduced into the recipient cells. We also found that anti-miR oligonucleotides introduced into the recipient cells can exhibit inhibitory effects on exosomal miRNA functions in vitro and in vivo. We believe that our strategy would be a promising one for targeting exosomal miRNAs. [ABSTRACT FROM AUTHOR]
- Subjects :
- EXOSOMES
DRUG delivery systems
MICRORNA
NUCLEIC acids
OLIGONUCLEOTIDES
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 12
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 144428298
- Full Text :
- https://doi.org/10.3390/pharmaceutics12060545