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Simultaneous Determination of (2R,3R)-Dihydromyricetin and Myricetin of Mongolia Medicine Sendeng-4 in RAT Plasma by Liquid Chromatography–Mass Spectrometry.
- Source :
- Journal of Analytical Chemistry; Jul2020, Vol. 75 Issue 7, p913-921, 9p
- Publication Year :
- 2020
-
Abstract
- A liquid chromatography−mass spectrometry method was developed for the simultaneous quantitation of (2R,3R)-Dihydromyricetin and Myricetin in rat plasma samples to facilitate analysis of samples collected after administration of SenDeng-4 medicine. The plasma was subjected to protein precipitation with HCl (containing 10% ascorbic acid) and analyzed using electrospray ionization mass spectrometry in selected ion monitoring mode with Paeoniflorin as an internal standard. Good linearity for the two compounds was observed. The intra- and inter-day precision of analysis was <10% for each compound. The present method was suitable for determining (2R,3R)-Dihydromyricetin and Myricetin in rat plasma after intravenous administration of SenDeng-4 to rats with sufficient sensitivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10619348
- Volume :
- 75
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Analytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 144423426
- Full Text :
- https://doi.org/10.1134/S1061934820070035