Back to Search
Start Over
Evaluation of a Novel Boron-Containing α-d-Mannopyranoside for BNCT.
- Source :
- Cells (2073-4409); May2020, Vol. 9 Issue 5, p1277, 1p
- Publication Year :
- 2020
-
Abstract
- Boron neutron capture therapy (BNCT) is a unique anticancer technology that has demonstrated its efficacy in numerous phase I/II clinical trials with boronophenylalanine (BPA) and sodium borocaptate (BSH) used as <superscript>10</superscript>B delivery agents. However, continuous drug administration at high concentrations is needed to maintain sufficient <superscript>10</superscript>B concentration within tumors. To address the issue of <superscript>10</superscript>B accumulation and retention in tumor tissue, we developed MMT1242, a novel boron-containing α-d-mannopyranoside. We evaluated the uptake, intracellular distribution, and retention of MMT1242 in cultured cells and analyzed biodistribution, tumor-to-normal tissue ratio and toxicity in vivo. Fluorescence imaging using nitrobenzoxadiazole (NBD)-labeled MMT1242 and inductively coupled mass spectrometry (ICP-MS) were performed. The effectiveness of BNCT using MMT1242 was assessed in animal irradiation studies at the Kyoto University Research Reactor. MMT1242 showed a high uptake and broad intracellular distribution in vitro, longer tumor retention compared to BSH and BPA, and adequate tumor-to-normal tissue accumulation ratio and low toxicity in vivo. A neutron irradiation study with MMT1242 in a subcutaneous murine tumor model revealed a significant tumor inhibiting effect if injected 24 h before irradiation. We therefore report that <superscript>10</superscript>B-MMT1242 is a candidate for further clinical BNCT studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- BORON-neutron capture therapy
RESEARCH reactors
NEUTRON irradiation
IRRADIATION
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 9
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Cells (2073-4409)
- Publication Type :
- Academic Journal
- Accession number :
- 144287267
- Full Text :
- https://doi.org/10.3390/cells9051277