Characterization of antigenic α-Gal-containing extracellular vesicles (EVs) from Trypanosoma cruzi.

The article discusses a study characterization of antigenic alfa-Gal-containing extracellular vesicles (EVs) from Trypanosoma cruzi. It reports tha Highly immunogenic alfa-Gal-containing epitopes found on trypomastigote GPI-anchored mucins (tGPI-mucins or TcMUC II) are strongly recognized by patients with Chagas disease (CD). It mentions alfa-Gal glycotopes have been used as BMKs for follow-up of chemotherapy in children and lately in adults with CD, and as prophylactic vaccine targets.