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Distortion product otoacoustic emission sensitivity to different solvents in a population of industrial painters.
- Source :
- International Journal of Audiology; Jun2020, Vol. 59 Issue 6, p443-454, 12p, 7 Charts, 6 Graphs
- Publication Year :
- 2020
-
Abstract
- Objective: To evaluate the ototoxic effect of the exposure to different organic solvents and noise using distortion product otoacoustic emissions (DPOAEs). Design: The exposure to different solvents was evaluated by measuring, before and at the end of the work-shift, the urinary concentrations of solvent metabolites used as dose biomarkers. The urinary concentrations of DNA and RNA oxidation products were also measured as biomarkers of oxidative damage. The simultaneous exposure to noise was also evaluated. DPOAEs and pure tone audiometry (PTA) were used as outcome variables, and were correlated to the exposure variables using mixed effect linear regression models. Study sample: Seventeen industrial painters exposed to a solvent mixture in a naval industry. A sample size of 15 was estimated from previous studies as sufficient for discriminating small hearing level and DPOAE level differences (5 dB and 2 dB, respectively) at a 95% confidence level. Results: Statistically significant associations were found between the DPOAE level and the urinary dose biomarkers and the oxidative damage biomarkers. DPOAE level and the logarithm of the metabolite concentration showed a significant negative correlation. Conclusions: DPOAE are sensitive biomarkers of exposure to ototoxic substances and can be effectively used for the early detection of hearing dysfunction. [ABSTRACT FROM AUTHOR]
- Subjects :
- AGE distribution
ANALYSIS of variance
AUDIOMETRY
BIOMARKERS
CHI-squared test
COMPARATIVE studies
CONFIDENCE intervals
DIAGNOSIS
INDUSTRIES
METABOLITES
NOISE
ORGANIC compounds
OTOACOUSTIC emissions
PAINT
QUESTIONNAIRES
RESEARCH funding
SHIPS
SOLVENTS
T-test (Statistics)
OCCUPATIONAL hazards
ENVIRONMENTAL exposure
MULTIPLE regression analysis
OXIDATIVE stress
OTOTOXICITY
INHALATION injuries
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 14992027
- Volume :
- 59
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- International Journal of Audiology
- Publication Type :
- Academic Journal
- Accession number :
- 144260995
- Full Text :
- https://doi.org/10.1080/14992027.2019.1710776