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Abnormal polarization of macrophage-like cells in the peripheral blood of patients with glioma.
- Source :
- Oncology Letters; Jul2020, Vol. 20 Issue 1, p947-954, 8p
- Publication Year :
- 2020
-
Abstract
- Glioma is a type of malignant tumor arising from glial cells of the brain or the spine. Circulation-derived macrophage infiltration is a characteristic of the glioma microenvironment. The polarization status of circulation-derived macrophages in patients with glioma remains unclear. Therefore, the present study aimed to evaluate the polarization status of circulation-derived macrophages in patients with glioma. A total of 40 patients with glioma and 38 healthy volunteers were recruited. The polarization status of macrophage-like cells in the peripheral blood of patients with glioma was evaluated. In addition, the associations between the polarization status of macrophage-like cells and glioma stage or the expression levels of the glioma tumor marker chitinase-3-like protein 1 (also termed YKL-40) were evaluated. The number of macrophage-like cells (CD115<superscript>+</superscript>CD1c<superscript>−</superscript>CD2<superscript>−</superscript>CD15<superscript>−</superscript>CD19<superscript>−</superscript>CD14<superscript>+</superscript>CD16<superscript>+</superscript>CD11b<superscript>+</superscript>) was higher in the peripheral blood of patients with glioma compared with that of healthy volunteers. There were fewer M1 macrophage-like cells, and more M2 macrophage-like cells were induced in the peripheral blood of patients with glioma compared with healthy controls. Specifically, the number of M2a/M2b macrophage-like cells increased, whereas that of M2c macrophage-like cells decreased in the peripheral blood of patients with glioma compared with healthy controls. The polarization status of macrophage-like cells in patients with glioma was not significantly associated with glioma stage or with the glioma marker YKL-40. Overall, the results of the present study revealed that the polarization status of macrophage-like cells in the peripheral blood of patients with glioma was abnormal, offering potential novel diagnostic and therapeutic targets, such as different macrophage subsets, for glioma. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLOOD cells
NEUROGLIA
VOLUNTEER recruitment
TUMOR markers
GLIOMAS
Subjects
Details
- Language :
- English
- ISSN :
- 17921074
- Volume :
- 20
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Oncology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 144218569
- Full Text :
- https://doi.org/10.3892/ol.2020.11602