Back to Search
Start Over
A Therapeutic Renaissance - Emerging Treatments for Atopic Dermatitis.
- Source :
- Acta Dermato-Venereologica; 2020 Special Issue, Vol. 100, p367-379, 13p
- Publication Year :
- 2020
-
Abstract
- Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease that is characterized by complex immune dysregulation and skin barrier dysfunction with a wide variety of clinical phenotypes. Until recently, conventional therapeutic modalities for AD remained rather non-specific despite AD's complex etiology. Failing to take into account the underlying inflammatory pathways led to treatments with inadequate efficacy or unacceptable long-term toxicities. We are currently in the midst of a therapeutic renaissance in AD. Recent progress in molecular medicine provides us a better understanding of the AD pathogenesis, suggesting a dominant helper T cell (Th) 2/Th22 response with a varying degree of Th1/Th17 overexpression. Targeted therapeutic agents including biologics and small molecule inhibitors in development hold promises for more effective and safer therapeutic approaches for AD. A better understanding of individual differences amongst AD patients will allow for a more tailored approach in the future. This review aims to cover the most promising emerging therapies in the field of atopic dermatitis utilizing recently published manuscripts and up-todate conference abstracts and presentations. [ABSTRACT FROM AUTHOR]
- Subjects :
- ATOPIC dermatitis
T helper cells
TREATMENT effectiveness
SKIN diseases
PATHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 100
- Database :
- Complementary Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 144216178
- Full Text :
- https://doi.org/10.2340/00015555-3515