Synthesis of the thapsigargins.

Authors :: Ley, Steven V.
Antonello, Alessandra
Balskus, Emily P.
Booth, David T.
Christensen, Søren B.
Cleator, Ed
Gold, Helen
Högenauer, Kiemens
Hünger, Udo
Myers, Rebecca M.
Oliver, Steven F.
Simic, Oliver
Smith, Martin D.
Søhoel, Helmer
Woolford, Alison J. A.
Source :: Proceedings of the National Academy of Sciences of the United States of America; 8/17/2004, Vol. 101 Issue 33, p12073-12078, 6p
Publication Year :: 2004
Abstract: The thapsigargins are a family of complex guaianolides with potent and selective Ca<superscript>2+</superscript>-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton. [ABSTRACT FROM AUTHOR]

Subjects :: NATURAL products
RAW materials
GREEN products
BIOLOGICAL products
COMMERCIAL products
RESEARCH

Language :: English
ISSN :: 00278424
Volume :: 101
Issue :: 33
Database :: Complementary Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 14420777
Full Text :: https://doi.org/10.1073/pnas.0403300101