(MIS)Use of the Adverse Outcome Pathway Concept for Assessing Endocrine Disruption in Nontarget Organisms.

The adverse outcome pathway (AOP) concept was developed to describe the linkage of events starting with chemical exposure to an apical effect, across levels of biological organization. In an AOP, the MIE is causally related to the AO through a series of key events (KEs) linked by key-event relationships (KERs). [Extracted from the article]