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Strychnos nux-vomica L. seed preparation promotes functional recovery and attenuates oxidative stress in a mouse model of sciatic nerve crush injury.
- Source :
- BMC Complementary Medicine & Therapies; 6/11/2020, Vol. 20 Issue 1, p1-11, 11p, 5 Graphs
- Publication Year :
- 2020
-
Abstract
- Background: Peripheral nerve injury is a debilitating condition that may lead to partial or complete motor, sensory and autonomic function loss and lacks effective therapy until date. Therefore, it is quite imperative to explore impending remedies for rapid and accurate functional retrieval following such conditions. Natural product-based intervention can prove effective to facilitate the process of functions regain. Methods: Here, we investigated the effect of processed Strychnos nux-vomica seeds at a dose of 250 mg/kg body weight in a mouse model of induced Sciatic nerve lesion in promoting the recovery of the functions. A compression injury was induced in the Sciatic nerve of the right leg in the mice. Sensory function recovery was evaluated by hot-plate and formalin tests, whereas the motor function retrieval was assessed by measuring muscle grip strength, sciatic functional index, and muscle mass restoration. Oxidative stress and blood cell count were measured by biochemistry and haematological analyses. Results: This study indicates that Strychnos nux-vomica seeds enhance the rate of recovery of both sensory and motor functions. It helps restore the muscle mass, attenuates total oxidant status and enhances the total anti-oxidant capacity of the biological system. Moreover, the treated animals manifested an enhanced glucose tolerance aptitude and augmented granulocyte and platelet counts. Improved oxidant control, enhanced glucose sensitivity and amended granulocyte and platelet counts are likely to contribute to the advantageous effects of Strychnos nux-vomica, and warrant further in-depth studies for deciphering possible mechanisms and identification of active constituent(s) responsible for these effects. Conclusion: Strychnos nux-vomica seed offers functional recovery promoting effects following a mechanical injury to the Sciatic nerve and the possible reasons behind this effect can be reduced oxidative stress and improved glycaemic control. Further and detailed investigations can unravel this mystery. [ABSTRACT FROM AUTHOR]
- Subjects :
- SCIATIC nerve injuries
ANIMAL experimentation
ANTIOXIDANTS
BIOCHEMISTRY
BLOOD testing
BLOOD cell count
ANALYTICAL chemistry
CONVALESCENCE
ESTERASES
GRANULOCYTES
GRIP strength
MICE
MOTOR ability
RESEARCH funding
SCIATIC nerve
SEEDS
SENSES
WOUNDS & injuries
PLANT extracts
OXIDATIVE stress
TREATMENT effectiveness
FUNCTIONAL assessment
DESCRIPTIVE statistics
GLYCEMIC control
Subjects
Details
- Language :
- English
- ISSN :
- 26627671
- Volume :
- 20
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Complementary Medicine & Therapies
- Publication Type :
- Academic Journal
- Accession number :
- 143725258
- Full Text :
- https://doi.org/10.1186/s12906-020-02950-3