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A behavioral genetic investigation of conceptualizations of resilience in a female twin sample.
- Source :
- Depression & Anxiety (1091-4269); Jun2020, Vol. 37 Issue 6, p532-539, 8p, 1 Diagram, 4 Charts, 1 Graph
- Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Great variability exists in response to stressful or traumatic events, leading to an interest in the construct of resilience as a trait and an outcome. The etiologic sources of variability across differing conceptualizations of resilience are poorly understood.<bold>Methods: </bold>Using behavioral genetic methods in a sample of 2,056 female twins, the present study sought to (a) examine the etiologic sources of a trait-based self-report measure of perceived resilience (PR), (b) determine the genetic and environmental overlap with an outcome-based measure of resilience, as defined by the absence of psychiatric symptoms after stressful life events, previously used by our research team (discrepancy-based psychiatric resilience [DBPR]), and (c) determine the etiologic overlap of these two resilience measures with major depressive disorder (MDD).<bold>Results: </bold>PR was modestly (11%) heritable. A moderate degree of genetic overlap (39%) and a nominal amount of environmental overlap (3%) were found between the two alternative measures of resilience. Genetic factors that influence PR accounted for 3% of MDD heritability, whereas 31% of MDD heritability was due to DBPR genetic factors.<bold>Conclusions: </bold>Findings of a higher genetic correlation between the outcome-based resilience measure and MDD compared to the trait-based measure and MDD suggest gene-finding efforts may benefit from considering the multifaceted nature of resilience and that resilience is best understood as both a phenotypically and genetically heterogeneous construct. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10914269
- Volume :
- 37
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Depression & Anxiety (1091-4269)
- Publication Type :
- Academic Journal
- Accession number :
- 143720485
- Full Text :
- https://doi.org/10.1002/da.23005