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From Specific γ‐CD/[Nb6Cl12(H2O)6]2+ Recognition to Biological Activity Tuning.
From Specific γ‐CD/[Nb6Cl12(H2O)6]2+ Recognition to Biological Activity Tuning.
- Source :
- Chemistry - A European Journal; 6/10/2020, Vol. 26 Issue 33, p7479-7485, 7p
- Publication Year :
- 2020
-
Abstract
- Specific molecular recognition of γ‐cyclodextrin (γ‐CD) by the cationic hexanuclear niobium [Nb6Cl12(H2O)6]2+ cluster complex in aqueous solutions results in a 1:1 supramolecular assembly {[Nb6Cl12(H2O)6]@γ‐CD}2+. NMR spectroscopy, isothermal titration calorimetry (ITC), and ESI‐MS were used to study the interaction between the inorganic cluster and the organic macrocycle. Such molecular association affects the biological activity of [Nb6Cl12(H2O)6]2+, decreasing its cytotoxicity despite enhanced cellular uptake. The 1:1 stoichiometry is maintained in solution over a large window of the reagents' ratio, but crystallization by slow evaporation produces a 1:2 host–guest complex [Nb6Cl12(H2O)6@(γ‐CD)2]Cl2⋅20 H2O featuring the cluster encapsulated between two molecules of γ‐CD. The 1:2 complex was characterized by XRD, elemental analysis, IR spectroscopy, and thermogravimetric analysis (TGA). Quantum chemical calculations were performed to model host–guest interaction. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 26
- Issue :
- 33
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 143704161
- Full Text :
- https://doi.org/10.1002/chem.202000739