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From Specific γ‐CD/[Nb6Cl12(H2O)6]2+ Recognition to Biological Activity Tuning.

From Specific γ‐CD/[Nb6Cl12(H2O)6]2+ Recognition to Biological Activity Tuning.

Authors :
Ivanov, Anton A.
Pozmogova, Tatiana N.
Solovieva, Anastasiya O.
Frolova, Tatiana S.
Sinitsyna, Olga I.
Lundovskaya, Olga V.
Tsygankova, Alphiya R.
Haouas, Mohamed
Landy, David
Benassi, Enrico
Shestopalova, Lidiya V.
Falaise, Clément
Cadot, Emmanuel
Shestopalov, Michael A.
Abramov, Pavel A.
Sokolov, Maxim N.
Source :
Chemistry - A European Journal; 6/10/2020, Vol. 26 Issue 33, p7479-7485, 7p
Publication Year :
2020

Abstract

Specific molecular recognition of γ‐cyclodextrin (γ‐CD) by the cationic hexanuclear niobium [Nb6Cl12(H2O)6]2+ cluster complex in aqueous solutions results in a 1:1 supramolecular assembly {[Nb6Cl12(H2O)6]@γ‐CD}2+. NMR spectroscopy, isothermal titration calorimetry (ITC), and ESI‐MS were used to study the interaction between the inorganic cluster and the organic macrocycle. Such molecular association affects the biological activity of [Nb6Cl12(H2O)6]2+, decreasing its cytotoxicity despite enhanced cellular uptake. The 1:1 stoichiometry is maintained in solution over a large window of the reagents' ratio, but crystallization by slow evaporation produces a 1:2 host–guest complex [Nb6Cl12(H2O)6@(γ‐CD)2]Cl2⋅20 H2O featuring the cluster encapsulated between two molecules of γ‐CD. The 1:2 complex was characterized by XRD, elemental analysis, IR spectroscopy, and thermogravimetric analysis (TGA). Quantum chemical calculations were performed to model host–guest interaction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09476539
Volume :
26
Issue :
33
Database :
Complementary Index
Journal :
Chemistry - A European Journal
Publication Type :
Academic Journal
Accession number :
143704161
Full Text :
https://doi.org/10.1002/chem.202000739