Challenging the Role of Diet-Induced Anti-Neu5Gc Antibodies in Human Pathologies.

Keywords: NeuGc; anti-Neu5Gc; autoantibodies; endothelial cells; epithelial cells; atheroma; cancers; humans EN NeuGc anti-Neu5Gc autoantibodies endothelial cells epithelial cells atheroma cancers humans 1 5 5 06/12/20 20200609 NES 200609 Introduction The thematic issue of I Frontiers in Immunology i , entitled "Human Antibodies Against the Dietary Non-Human Neu5Gc-Carrying Glycans in Normal and Pathological States", benefits from an extensive fundamental review of previous studies on N-glycolylneuraminic acid (Neu5Gc) in humans [([1]) for recent review and citations therein] and from studies on anti-Neu5Gc antibodies (A-GcAbs) in I Cmah i SP -/- sp mice that, similar to humans, lack a functional cytidine monophosphate N-acetylneuraminic acid hydroxylase (CMAH), thereby allowing Neu5Gc synthesis ([2]). As previously mentioned, xenosialitis, which is restricted to human pathologies in this opinion article, has been proposed as a "logical" basis for deleterious effects that would result from I in situ i interactions of A-GcAbs, which are present in human sera and diet-derived Neu5Gc deposits on certain human cells ([1]). Abbreviations A-GcAbs Anti-Neu5Gc antibodies CAD Coronary artery disease CMAH Cytidine monophosphate N-acetylneuraminic acid hydroxylase CRC Colorectal cancer EBV Epstein-Barr virus IMN Infectious mononucleosis ECs Endothelial cells Neu5Gc N-glycolylneuraminic acid MS Multiple sclerosis SSD Serum sickness disease. [Extracted from the article]