اثر عصاره هیدروالکلی قارچ دنبلان بر سطح سرمی هورمو نهای تیروئیدی در موش صحرایی نر

Background and Aim Thyroid gland makes Thyroxine (T4) and Triiodothyronine (T3) hormones. These hormones are really effective in regulating and control of basal metabolism. The purpose of this study was to assess the effect of hydroalcoholic extract of Terfezia Boundary (TB) on the serum level of thyroid hormones. Methods & Materials In this experimental study, 30 male Wistar rats (weighing 200±10 g) were selected and divided into five groups of 6 including control, sham (received normal saline) and three experimental groups received TB with 75, 150 and 300 mg/kg doses via intraperitoneal injection for 14 days. Samples from all groups were collected at the end of the 14th day directly from the heart to evaluate thyroid hormone. The data were statistically analyzed in SPSS V. 12. Ethical Considerations This study was approved by the Research Ethics Committee of Ardabil University of Medical Sciences (Code: IR.ARUMS.REC.1396.48). Results The results of this study showed that the T3 and T4 levels in the experimental groups 2 (150 mg/kg) and 3 (300 mg/kg) increased significantly compared to the control group (P<0.001 and P<0.01, respectively). The Thyroid Stimulating Hormone (TSH) level in the experimental groups 1 (75 mg/kg), 2 (150 mg/kg) and 3 (300 mg/kg) decreased significantly compared to the control group (P<0.05, P<0.001, P<0.001, respectively). Conclusion Hydroalcoholic extract of TB can increase the serum levels of thyroid hormones and reduce TSH level. [ABSTRACT FROM AUTHOR]