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miR-548b-3p functions as a tumor suppressor in lung cancer.
- Source :
- Lasers in Medical Science; Jun2020, Vol. 35 Issue 4, p833-839, 7p
- Publication Year :
- 2020
-
Abstract
- miR-548-3p is one of the members of miR-548 family, a large primate-specific miRNA gene family. The role of miR-548-3p in lung cancer was less studied. In this study, we found the expression of miR-548-3p was lower both in clinical tumor specimens and lung cancer cells compared with normal controls. In vitro, miR-548-3p inhibited lung cancer cell growth and promoted cell apoptosis at the S stage of cell cycle. The underlying mechanism of miR-548b-3p-induced cell proliferation inhibition and apoptosis may be associated with the inhibition of PI3K/AKT signaling pathway. In vivo, miR-548b-3p also suppressed tumor growth in xenografts model of lung cancer cells. Our results indicated that miR-548b-3p might be an anti-tumor target of lung cancer in the future. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02688921
- Volume :
- 35
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Lasers in Medical Science
- Publication Type :
- Academic Journal
- Accession number :
- 143492985
- Full Text :
- https://doi.org/10.1007/s10103-019-02865-7