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Percutaneous mastoid electrical stimulator improves Poststroke depression and cognitive function in patients with Ischaemic stroke: a prospective, randomized, double-blind, and sham-controlled study.
- Source :
- BMC Neurology; 5/29/2020, Vol. 20 Issue 1, p1-9, 9p, 2 Diagrams, 4 Charts
- Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Poststroke depression can lead to functional dependence, cognitive impairment and reduced quality of life. The aim of this study was to evaluate the effects of a percutaneous mastoid electrical stimulator (PMES) plus antidepressants on poststroke depression and cognitive function.<bold>Methods: </bold>This study was a prospective, randomized, double-blind, and sham-controlled study. A total of 258 clinically depressed ischaemic stroke patients within 14 days of index stroke were randomly assigned to the PMES plus antidepressant (PMES group, N = 125) and sham plus antidepressant (sham group, N = 133) groups. All patients underwent the Montreal Cognitive Assessment (MoCA) and Hamilton Rating Scale for Depression (HRSD) test at 2 weeks (baseline), and 6 months(M6) after ischaemic stroke. Primary outcomes were the percentage of patients showing a treatment response (≥50% reduction in HRSD score) and depression remission (HRSD score ≤ 9) at 6 months. The secondary outcome was the percentage of patients with a MoCA score < 26.<bold>Results: </bold>The percentages of patients showing a treatment response and depression remission were significantly higher in the PMES group than in the sham group (57.60% vs 41.35%, P = 0.009; 44.00% vs 29.32%, P = 0.014 respectively). The mean value of the HRSD score change [M (month)6-baseline] was significantly higher in the PMES group than in the sham group at 6 months (- 11.93 ± 5.32 vs - 10.48 ± 6.10, P = 0.036, respectively). The percentage of patients with MoCA scores < 26 was lower in the PEMS group than in the sham group (12.0% vs 24.06%, P = 0.012,respectively), and the mean value of the MoCA score change (M6-baseline) was higher in the PMES group than in the sham group (3.50 ± 2.55 vs 2.72 ± 2.52, P = 0.005, respectively).<bold>Conclusion: </bold>These findings demonstrate that PMES adjunctive to antidepressant therapy is effective in reducing depression, achieving remission in the short term, and improving cognition.<bold>Trial Registration: </bold>This trial was retrospectively registered (registration number: ChiCTR1800016463) on 03 June 2018. [ABSTRACT FROM AUTHOR]
- Subjects :
- HAMILTON Depression Inventory
STROKE patients
COGNITIVE ability
MONTREAL Cognitive Assessment
COGNITION disorders
ANTIDEPRESSANTS
RESEARCH
STROKE
MASTOID process
RESEARCH methodology
COGNITION
EVALUATION research
MEDICAL cooperation
TREATMENT effectiveness
COMPARATIVE studies
RANDOMIZED controlled trials
PSYCHOLOGICAL tests
MENTAL depression
BLIND experiment
QUALITY of life
RESEARCH funding
ELECTROTHERAPEUTICS
COMBINED modality therapy
STATISTICAL sampling
CEREBRAL ischemia
LONGITUDINAL method
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 14712377
- Volume :
- 20
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 143491912
- Full Text :
- https://doi.org/10.1186/s12883-020-01795-0